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The term “antihistamine” generally is used to describe those medications that antagonize histamine activity at H1 receptors. Currently the only FDA-approved histamine antagonist medications block the effects of histamine at H1 or H2 receptor sites.
Manage, don’t accept adverse ‘calming’ effect Sedation is a frequent side effect of antipsychotics, especially at relatively high doses.
Safety and tolerability: how do newer generation ”atypical” antipsychotics compare?
If you initiate a more sedating antipsychotic acutely, switching to a less sedating agent when the patient is stable and the illness is in remission may support adherence and improve outcomes.
Early-onset hypothesis of antipsychotic drug action: a hypothesis tested, confirmed and extended.
Treatment of special populations with the atypical antipsychotics.
Aripiprazole: a dopamine-serotonin system stabilizer [abstract no.